Best Medical Practice Management Software in the US

As digital tools become the standard for managing patient care, data, and operations, your business needs a reliable solution to stay competitive and meet growing expectations.

Julian, Author

Last updated: September, 2025

Most Popular

8.9

Primary Care Focused

Purpose-built for small practices - 83% of customers are 1-5 clinicians
Pricing tied to practice collections, not flat fees
Access network insights from 160,000+ providers for performance benchmarking
Dedicated Customer Success Manager with unlimited 1:1 coaching sessions

Visit AthenaHealth

athenahealth provides cloud-based healthcare software for independent medical practices and ambulatory care centers. Their athenaOne platform integrates EHR, practice management, revenue cycle management, and patient engagement into a single solution.

The platform connects over 160,000 healthcare providers in a network that enables data sharing and performance benchmarking. athenahealth uses a percentage-of-collections pricing model where their revenue ties directly to practice performance, including comprehensive support services for claims management and denial resolution.

Recognized as 2024 Best in KLAS overall solution for independent physician practices, the platform supports various medical specialties with emphasis on automated workflows, interoperability, and data-driven insights to improve operational efficiency and financial performance.

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Editor's Choice

8.9

Complete Medical Practice Platform

15+ clinical and medical billing-focused dashboards
Certified, award-winning healthcare software with 25+ years proven experience
Integrated full suite with electronic prescribing, EHR, and practice management
24/7 cloud-based access with free mobile applications for any device

Visit RXNT Save 10% with annual plans

RXNT provides certified, award-winning healthcare software for medical practices and health organizations of all sizes with over 20 years of proven experience. Their truly-integrated Full Suite platform contains Electronic Prescribing, Electronic Health Records with Patient Portal, Practice Management with Medical Billing and Scheduling, ensuring nothing falls through the cracks because all systems communicate natively.

With quick setup in just weeks, affordable pricing, 24/7 cloud-based access, premium US-based support, and free mobile applications accessible from any device, RXNT helps thousands of providers focus on delivering patient care while maximizing efficiency and profitability.

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Over 40+ specialty-specific solutions
Comprehensive EHR and practice management software
Save your providers up to 2.5 hours a day with AI-powered documentation.
Trusted by practices from small to enterprise scale
Closed-loop patient experience

NextGen Healthcare is the #1-ranked practice management platform by Black Book Research for eight consecutive years, with first-place EHR ratings in cardiology, internal medicine, neurosurgery, pediatrics, and sleep medicine. Their integrated healthcare solutions improve work-life balance and clinical outcomes through AI-powered Ambient Assist technology that generates notes with 90% accuracy, saving providers up to 2 hours daily. More than just software, NextGen serves as a trusted partner committed to enhancing the lives of everyone in healthcare.

Frequently Asked Questions

What features should you prioritize when comparing medical practice management software?

Focus on these essential capabilities:

Patient scheduling
Electronic billing
Insurance verification
Claims management
Revenue cycle analytics
Patient portal access
EHR integration
Automated reminders

How much does medical practice management software cost?

Medical practice management software typically costs between $50 to over $500 per provider per month for cloud-based solutions, though prices can range from under $10 for basic plans to over $6,000 for premium options. The price depends heavily on your practice size, required features like EHR integration and patient portals, and whether you choose cloud-based or on-premises deployment. Many vendors offer custom pricing for larger practices with specialized needs.

How long does it take to implement medical practice management software?

Plan for 4-8 weeks for full implementation depending on your practice size and data complexity. The process includes data migration from your current system, staff training, and workflow setup. Most vendors provide dedicated implementation support, and you can often run both old and new systems temporarily to ensure smooth transition without disrupting patient care.

Do I need separate software for EHR and practice management?

Most modern solutions combine both EHR and practice management in one integrated platform, which eliminates duplicate data entry and reduces costs. All-in-one systems ensure patient records, scheduling, and billing work seamlessly together. Separate systems can create workflow disruptions and require costly integrations to share data properly.

Our Favorites

Editor's Choice

8.9

Certified, award-winning healthcare software with over 20 years of experience serving medical practices through truly-integrated Full Suite platform featuring Electronic Prescribing, EHR, Practice Management, quick setup in weeks, and premium US-based support.

Save 10% with annual plans

Visit RXNT

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