Best Medical Practice Management Software in the US

As digital tools become the standard for managing patient care, data, and operations, your business needs a reliable solution to stay competitive and meet growing expectations.

Julian, Author
Last updated: June, 2025
Editor's Choice
9.5
Specialty Customization
  • Over 40+ specialty-specific solutions
  • Comprehensive EHR and practice management software
  • Save your providers up to 2.5 hours a day with AI-powered documentation.
  • Trusted by practices from small to enterprise scale
  • Closed-loop patient experience
Visit NextGen Healthcare Free demo

NextGen Healthcare is the #1-ranked practice management platform by Black Book Research for eight consecutive years, with first-place EHR ratings in cardiology, internal medicine, neurosurgery, pediatrics, and sleep medicine. Their integrated healthcare solutions improve work-life balance and clinical outcomes through AI-powered Ambient Assist technology that generates notes with 90% accuracy, saving providers up to 2 hours daily. More than just software, NextGen serves as a trusted partner committed to enhancing the lives of everyone in healthcare.

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9.3
Behavioral Health Focused
Visit Ensora Health 21-day free trial

Ensora Health provides unified practice management software specifically designed for behavioral health practices. Their integrated platform combines EHR, practice management, and revenue cycle solutions in one system, eliminating the daily frustrations of juggling multiple software tools.

With modern architecture that easily scales as practices grow, Ensora serves everyone from solo practitioners to large community behavioral health clinics, substance use centers, and ABA practices. Trusted by over 200,000 providers across 28,000+ practices, their specialized approach helps behavioral health professionals focus on patient care instead of administrative complexity.

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Most Popular
9.1
Primary Care Focused
Visit AthenaHealth

athenahealth provides cloud-based healthcare software for independent medical practices and ambulatory care centers. Their athenaOne platform integrates EHR, practice management, revenue cycle management, and patient engagement into a single solution.

The platform connects over 160,000 healthcare providers in a network that enables data sharing and performance benchmarking. athenahealth uses a percentage-of-collections pricing model where their revenue ties directly to practice performance, including comprehensive support services for claims management and denial resolution.

Recognized as 2024 Best in KLAS overall solution for independent physician practices, the platform supports various medical specialties with emphasis on automated workflows, interoperability, and data-driven insights to improve operational efficiency and financial performance.

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8.8
  • 15+ clinical and medical billing-focused dashboards
  • Certified, award-winning healthcare software with 25+ years proven experience
  • Integrated full suite with electronic prescribing, EHR, and practice management
  • 24/7 cloud-based access with free mobile applications for any device

RXNT provides certified, award-winning healthcare software for medical practices and health organizations of all sizes with over 20 years of proven experience. Their truly-integrated Full Suite platform contains Electronic Prescribing, Electronic Health Records with Patient Portal, Practice Management with Medical Billing and Scheduling, ensuring nothing falls through the cracks because all systems communicate natively.

With quick setup in just weeks, affordable pricing, 24/7 cloud-based access, premium US-based support, and free mobile applications accessible from any device, RXNT helps thousands of providers focus on delivering patient care while maximizing efficiency and profitability.

What to look for in Medical Software

In 2025, medical software is essential for improving efficiency, accuracy, and compliance across the healthcare industry. As digital tools become the standard for managing patient care, data, and operations, businesses need reliable solutions to stay competitive and meet growing expectations.

What is medical software?
Medical software includes digital tools used in healthcare for clinical, diagnostic, and administrative functions. This ranges from systems that store patient data to software that assists in diagnostics. Choosing the right type of software is crucial for businesses to meet specific healthcare needs and comply with regulations—whether you aim to serve hospitals, clinics, or individual practitioners.
What are examples of medical software?
Common examples include:
  • Electronic Health Records (EHRs) – for managing patient data
  • Medical billing software – for handling insurance claims
  • Telemedicine platforms – for remote care delivery
  • Radiology/PACS software – for imaging and diagnostics
    Selecting a clear niche within these categories is essential, as each requires unique integrations, features, and compliance efforts.
Is FDA approval required for medical software?
If your software performs diagnostic functions or guides clinical decisions, it’s classified as a Software as a Medical Device (SaMD) and may require FDA approval. Businesses must carefully determine if their product falls under FDA jurisdiction early in development, as this impacts cost, timeline, and legal risk.
What regulations apply to medical software in the U.S.?
At a minimum, your software must comply with:
  • HIPAA (for data privacy and security)
  • FDA regulations (if it has clinical functionality)
  • ONC certification (if it’s an EHR product)
    Compliance is non-negotiable in the U.S. healthcare industry. Selecting the right type of software and preparing for regulatory compliance from day one helps avoid penalties, delays, and custome

Editor’s Top 3

9.5
Built by some of the brightest minds in software development, NextGen Healthcare EHR solutions are informed by input from practicing clinicians and revenue cycle experts.
Visit NextGen Healthcare
Free Demo!
9.3
Unified practice management software for behavioral health. Integrated EHR, billing, and operations trusted by 200,000+ providers.
Visit Ensora Health
21-day free trial
Cloud-based EHR and practice management platform serving independent healthcare practices with comprehensive revenue cycle management and patient engagement tools.
Visit AthenaHealth
Free Demo!

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