Top Medical Practice Management Software in the US

As digital tools become the standard for managing patient care, data, and operations, your business needs a reliable solution to stay competitive and meet growing expectations.

Julian, Author

Last updated: May, 2025

9.3

Behavioral Health Focused

Trusted by 200,000+ providers across 28,000+ practices
Purpose-built for mental, behavioral & rehabilitative therapists
AI-enabled solutions spanning practice management to billing
Supports everyone from solo practitioners to large practices
Comprehensive EMR, e-prescribing, and billing integration

Visit Ensora Health 21-day free trial

Ensora Health provides unified practice management software specifically designed for behavioral health practices. Their integrated platform combines EHR, practice management, and revenue cycle solutions in one system, eliminating the daily frustrations of juggling multiple software tools.

With modern architecture that easily scales as practices grow, Ensora serves everyone from solo practitioners to large community behavioral health clinics, substance use centers, and ABA practices. Trusted by over 200,000 providers across 28,000+ practices, their specialized approach helps behavioral health professionals focus on patient care instead of administrative complexity.

Learn More

9.5

Specialty Customization

Over 40+ specialty-specific solutions
Comprehensive EHR and practice management software
Save your providers up to 2.5 hours a day with AI-powered documentation.
Trusted by practices from small to enterprise scale
Closed-loop patient experience

Visit NextGen Healthcare Free demo

NextGen Healthcare is the #1-ranked practice management platform by Black Book Research for eight consecutive years, with first-place EHR ratings in cardiology, internal medicine, neurosurgery, pediatrics, and sleep medicine. Their integrated healthcare solutions improve work-life balance and clinical outcomes through AI-powered Ambient Assist technology that generates notes with 90% accuracy, saving providers up to 2 hours daily. More than just software, NextGen serves as a trusted partner committed to enhancing the lives of everyone in healthcare.

Learn More

9.7

User-friendly interface
Telehealth integration
Customizable templates
Client portal

Visit SimplePractice 30-day free trial

Discover SimplePractice, the premium all-in-one EHR solution for effortless practice management. Trusted by over 185,000 therapists and health professionals worldwide, it boasts a remarkable 96% practitioner satisfaction rate. Whether you’re a solo practitioner or part of a larger team, our platform caters to practices of all sizes.

Streamline documentation, scheduling, client sessions, and more, all in one secure solution. Empower your clients with a user-friendly client portal and offer HIPAA-compliant telehealth appointments. Simplify your workload with integrated tools for scheduling, billing, insurance claims, and measurement-based care. Experience the simplicity and success of SimplePractice today.

Learn More

9.1

Cloud-based solution
Clinical decision support
Automated workflows
User-friendly interface

Visit Athena

8.1

Cloud-based solution
Mobile accessibility
Integration with third-party apps

Visit DrChrono

Discover DrChrono, the cloud-based EHR, medical billing software, and RCM service that empowers your practice to deliver optimal patient care.

Practice Medicine, Not Administration, with customizable clinical notes, time-saving shortcuts, and HIPAA-compliant telehealth capabilities. Benefit from our experienced RCM team’s 96% clean claims rate and enjoy features like online scheduling, self-check-in, and a mobile EHR app for care on-the-go.

Learn More

7.7

Have a choice of RCM solutions
AI-Powered
Join 110,000+ facilities

7.5

No software to download
Expert support 24/7
Flexible billing options

What to look for in Medical Software

In 2025, medical software is essential for improving efficiency, accuracy, and compliance across the healthcare industry. As digital tools become the standard for managing patient care, data, and operations, businesses need reliable solutions to stay competitive and meet growing expectations.

What is medical software?

Medical software includes digital tools used in healthcare for clinical, diagnostic, and administrative functions. This ranges from systems that store patient data to software that assists in diagnostics. Choosing the right type of software is crucial for businesses to meet specific healthcare needs and comply with regulations—whether you aim to serve hospitals, clinics, or individual practitioners.

What are examples of medical software?

Common examples include:

Electronic Health Records (EHRs) – for managing patient data
Medical billing software – for handling insurance claims
Telemedicine platforms – for remote care delivery
Radiology/PACS software – for imaging and diagnostics
Selecting a clear niche within these categories is essential, as each requires unique integrations, features, and compliance efforts.

Is FDA approval required for medical software?

If your software performs diagnostic functions or guides clinical decisions, it’s classified as a Software as a Medical Device (SaMD) and may require FDA approval. Businesses must carefully determine if their product falls under FDA jurisdiction early in development, as this impacts cost, timeline, and legal risk.

What regulations apply to medical software in the U.S.?

At a minimum, your software must comply with:

HIPAA (for data privacy and security)
FDA regulations (if it has clinical functionality)
ONC certification (if it’s an EHR product)
Compliance is non-negotiable in the U.S. healthcare industry. Selecting the right type of software and preparing for regulatory compliance from day one helps avoid penalties, delays, and custome

Editor’s Top 3

9.7

SimplePractice is more than an EHR software. It’s your all-in-one practice management software for running a simpler business and delivering a great client experience.

Visit SimplePractice

9.5

Built by some of the brightest minds in software development, NextGen Healthcare EHR solutions are informed by input from practicing clinicians and revenue cycle experts.

Visit NextGen Healthcare

Visit Athena

Who we are

Tech.co is a leading business technology authority, here to help you know more about tech and find the best solutions to work smarter and grow securely. We assist over half a million customers each month in making the right choices for their needs, with our comparison charts, guides, and reviews.

The right tech can help you find new and more efficient ways of running your operation, retain and attract loyal customers, protect your assets from security risks, or even add entirely new revenue streams. We should know, because we’ve been there; Tech.co started out as a simple community-building Tech Cocktail event, back in 2006, and has transformed into a fully-fledged media company.

Top Medical Practice Management Software in the US

What to look for in Medical Software

Editor’s Top 3

Who we are

Advertising disclosure